The use of the synthetic analogue of leucin-encephaline in complementary therapy of dogs with chronic pancreatitis

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dc.contributor.authorMilastnaia, A.G.
dc.date.accessioned2023-04-11T08:29:12Z
dc.date.available2023-04-11T08:29:12Z
dc.date.issued2020
dc.description.abstractA review of the problem of treating dogs for pancreatitis with peptide drugs is presented. The main attentin is paid to the analysis of the use of somatostatin, octreotide and the synthetic analogue of leucine-enkephalin – dalargin. Despite numerous studies of the therapeutic effects of these agents for acute pancreatitis and pancreatic necrosis in humane medicine, there is no definitive answer about their efficacy in dogs due to the lack of work performed in accordance with the criteria of evidence-based medicine. The use of dalargin in the complex therapy of dogs with chronic pancreatitis, eliminates or reduces pain and dyspeptic phenomena, contributes to the onset of positive changes at the same time a number of positive changes in the functional state of the pancreas manifested by decreased serum amylase activity 3 times, pancreatic lipase in the 1,9 times. Studies carried out on dogs, patients with chronic pancreatitis, it is determined that against the background of treatment of synthetic analogue Leukin-enkefaline – Dalagin. The intensity of pain decreased (up to 5 days in 90% of patients), decreased amylase and pancreatic lipase activity and TBK-active product (malonic dialdehyde, MDA) in their blood serum. Ultrasound showed data on the reduction of pancreatic edema, in 7 sick dogs, its sizes were restored to indicators in healthy animals.uk_UA
dc.identifier.citationThe use of the synthetic analogue of leucin-encephaline in complementary therapy of dogs with chronic pancreatitis/ A.G. Milastnaia // Український часопис ветеринарних наук. – К. : НУБіП України, 2020. - Том 11, № 1. – С. 52 – 58uk_UA
dc.identifier.urihttps://dglib.nubip.edu.ua/handle/123456789/9674
dc.language.isoenuk_UA
dc.publisherНУБіП Україниuk_UA
dc.subjectchronic pancreatitisuk_UA
dc.subjectacute pancreatitisuk_UA
dc.subjectdogsuk_UA
dc.subjectdalarginuk_UA
dc.subjectserum amylaseuk_UA
dc.subjectpancreatic lipaseuk_UA
dc.titleThe use of the synthetic analogue of leucin-encephaline in complementary therapy of dogs with chronic pancreatitisuk_UA
dc.typeStattyauk_UA

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Український часопис ветеринарних наук - 2020