Український часопис ветеринарних наук

Постійне посилання на фондhttps://dglib.nubip.edu.ua/handle/123456789/8033

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Anamnestic, clinical and pathomorphological characteristics of malignant mammary tumors and dysplasia in dogs
(НУБіП України, 2019) Mykhalenko, N.I.; Kmitevych, E.O.
Parameters of 37 canine mammary malignant tumors and 13 dysplasia were compared. The age of an animal at the time of treatment in veterinary clinic, the age of the first factors of neoplasm, the number of births during life and the period of the last one, feeding nature, pseudo pregnancy and lactaton cases, the number and locaton of affected mammary gland, neoplasm macro characteristcs were considered. The size of the leter was determined with a view to three factors, the occurrence of capsules in neoplasms was ranked in points. The intensity of lactaton malfuncton was determined under the same method. Canine mammary dysplasia was examined at an earlier age than malignant tumors. This is partly due to the earlier onset than in the case of malignant tumors. At the same tme, period between cancer discovery and treatment in the later case was much shorter. It may state faster growth of tumors in case of malignancy than in mammary dysplasia. A significant difference in neoplasms size - malignant tumor and dysplasia is the proof thereof.Study of the influence of the number of births in the occurrence of different mammary neoplasms showed that dogs with dysplasia gave birth twice as less than those with diagnosed malignant tumors. The period between the last birth and identficaton of factors of disease for both groups of animals was the same. There was no significant difference also in the frequency of cases with lactaton malfuncton in dogs with mammary malignant tumors and dysplasia. Groups of animals with mammary malignant tumors and dysplasia differed on such characteristcs as frequency of tumors with full, partal or no capsule, and the average number of mammary gland affected and their localizaton.
Dynamics of some biochemical indicators in canine pRBC during storage period
(ВЦ НУБіП України, 2018) Tsvilikhovski, M.I.; Yakymchuk, I.M.; Makaryn, A.O.; Yakymchuk, O.M.; Marynyuk, M.O.
According to the standards of humane medicine, a large concentration of extracellular potassium may accumulate in the human packed red blood cells (pRBCs) during storage. Therefore, during transfusion to the recipient of such pRBCs, there is a risk of developing hyperkalaemia. This is one of the reasons for a significant restriction of the use of erythrocytic mass in humane medicine, sometimes after two weeks of storage. In veterinary medicine there is no research on the dynamics of accumulation of potassium and lactate in the canine pRBCs. The aim of the study was to determine the concentrations of potassium and lactate in the canine pRBC for different periods of its storage. According to the results of the research, the concentration of potassium during the 35-day storage period of the canine pRBCs significantly increased in 2.1 times from 3.89 ± 0.16 mmol/L to 8.12 ± 0.26 mmol/L, and lactate concentration increased in 10.7 times from 1.8 ± 0.07 mmol/L to 19.3 ± 0.25 mmol/L, followed by a rapid decrease in these parameters after the 21st day of pRBC storage. It was established that the concentrations of potassium and lactate in the canine pRBC on the 35th day of storage is safe for its transfusion to animals. Moreover, the level of lactate in the canine pRBC can be used as a criterion for its suitability for transfusion to patients. In the future, it is important to determine the dynamics of changes in the morphological parameters of the erythrocytic mass of dogs for different periods of its storage.
The use of the synthetic analogue of leucin-encephaline in complementary therapy of dogs with chronic pancreatitis
(НУБіП України, 2020) Milastnaia, A.G.
A review of the problem of treating dogs for pancreatitis with peptide drugs is presented. The main attentin is paid to the analysis of the use of somatostatin, octreotide and the synthetic analogue of leucine-enkephalin – dalargin. Despite numerous studies of the therapeutic effects of these agents for acute pancreatitis and pancreatic necrosis in humane medicine, there is no definitive answer about their efficacy in dogs due to the lack of work performed in accordance with the criteria of evidence-based medicine. The use of dalargin in the complex therapy of dogs with chronic pancreatitis, eliminates or reduces pain and dyspeptic phenomena, contributes to the onset of positive changes at the same time a number of positive changes in the functional state of the pancreas manifested by decreased serum amylase activity 3 times, pancreatic lipase in the 1,9 times. Studies carried out on dogs, patients with chronic pancreatitis, it is determined that against the background of treatment of synthetic analogue Leukin-enkefaline – Dalagin. The intensity of pain decreased (up to 5 days in 90% of patients), decreased amylase and pancreatic lipase activity and TBK-active product (malonic dialdehyde, MDA) in their blood serum. Ultrasound showed data on the reduction of pancreatic edema, in 7 sick dogs, its sizes were restored to indicators in healthy animals.

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