Protective activity of a complex antigen for the design of associated vaccine with the purpose of control of bacterial infections of powder

Abstract

Significant damage to pig farms with traditional and sometimes industrial technology, the maintenance of association with bacterial infections - salmonella, pastereliosis, esherichiosis. Previously, for the control of the well-being of farms, a commercial PPD vaccine (pasteurellosis, paratyphoid, diplococcal infection) was used. Currently, the drug loses its protective capacity due to the proliferation of microorganisms in aetibic families with altered antigenic structure. To create a commercial drug of a new specimen, a number of studies have been carried out on its design and testing on a sensitive livestock. An experimental sample of an associated antigen proved to be quite competitive in immunological activity compared with commercial PPD vaccine. The protective activity of blood serum of animals after its application was 92 %, the level of T- and B-lymphocytes increased by 39.5 % and 22.7 %, respectively, the phagocytic activity in experimental group pigs increased by 7.1 % in comparison with the control (4.8 %). The survival of the pigs used by the experimental antigenic specimen in the groups after weaning was 99.5 % compared to the control group (75.4 %). Average daily gain of pigs the experimental group was at 592.4 ± 3.2 g, and at control – 412,4 ± 5,7 g.